MCAM Workflows Manual

Step-by-step guides for MCAM acquisition and analysis workflows. These pages are generated from the master Workflows Manual Google Doc.

Introduction

The purpose of this manual is to guide users of the Multi-Camera Array Microscope (MCAM) through MCAM workflows with step by step instructions…

Introduction
Acquire an Image

Capturing an image is the simplest form of data acquisition within the MCAM platform.

Acquire an Image
Acquire a Z Stack

A z-stack is a series of images taken at different focal planes along the z-axis, capturing a 3D representation of a specimen. It’s commonly used in…

Acquire a Z Stack
Acquire an XYZ Stack

In Screening Mode with a 96-well plate it is often useful to acquire a z-stack at high resolution, however because the optical head views twenty four…

Acquire an XYZ Stack
Acquire a Video

Videos can be streamed and acquired from all cameras of the MCAM simultaneously.

Acquire a Video
Tools

Available both in the MCAM Acquisition Software and the MCAM Viewer Software.

Tools
Recommended Model Organism Video Acquisition Parameters
Recommended Model Organism Video Acquisition Parameters
Create a Well Alignment File

This step creates a file that will be used to detect well plate wells for analysis.

Create a Well Alignment File
Compressing .nc Dataset Files

This step compresses the .nc dataset file to prepare it for analysis.

Compressing .nc Dataset Files
Zebrafish Tracking

The Ramona MCAM supports fully automated zebrafish tracking across 96-, 24-, and custom 12-well plates in Visible and Infrared transmission…

Zebrafish Tracking
Zebrafish Segmentation - Fluorescence

The Ramona MCAM supports fully automated segmentation of zebrafish from single frame and stack datasets. This functionality can be used to define a…

Zebrafish Segmentation - Fluorescence
Zebrafish Morphology and Segmentation - BrightField

The Ramona MCAM supports fully automated segmentation of zebrafish from both single-frame and stack datasets. Users can choose from seven…

Zebrafish Morphology and Segmentation - BrightField
Diffuser Riser for Zebrafish Morphology and Segmentation

The Diffuser Riser is designed to optimize imaging conditions when running experiments in Screening mode on the Kestrel. The diffuser riser provides…

Diffuser Riser for Zebrafish Morphology and Segmentation
Activity Metric

Activity metric analysis provides a rapid method for computing movement in a video. This is accomplished by subtracting each pair of adjacent frames…

Activity Metric
Best Focus Panel

This feature allows users to find in-focus images for each image in the overall array.

Best Focus Panel
Full Well Scan

A full-well scan allows users to scan the entire well of the well plates used in contrast to imaging a portion of wells imaged in a single-position…

Full Well Scan
Analysis

Available in the MCAM Viewer Software.

Analysis
Machine Learning

Available in the MCAM Viewer Software.

Machine Learning